Insecticide China News 1702

Date: 2017-03

“Recommended article for Insecticides China News 1702:

Guadipyr: additional neonicotinoid insecticide harmless to bees to be registered in China

On 20 Jan., 2017, the Institute for the Control of Agrochemicals, Ministry of Agriculture (ICAMA) released the 1st list of to-be-issued temporary pesticide registration certificates, which included Hefei Xingyu Chemical Co., Ltd. (Xingyu Chemical)’s guadipyr 96% TC and guadipyr 20% SC, both of low toxicity. Guadipyr 20% SC targets rice plant hoppers and cabbage aphids, and its recommended usage amounts for these pests are 60-105 g/hm2 and 30-45 g/hm2 respectively (both based on active ingredient, spraying). The two were the first registrations of guadipyr in China.

Guadipyr, which combines the chemical structures of neonicotinoids and semicarbazone insecticides, is a new member of the neonicotinoid family and was developed by China Agricultural University. The preparation method and application of this innovative high efficacy insecticide has already been patented.

Xingyu Chemical was granted the exclusive right to develop guadipyr in 2008 and began R&D work (product lab code: ZNQ-08056):
2009: trial tests on efficacy against cabbage aphids were conducted by the Anhui Academy of Agricultural Sciences (by commission)
2010: trial tests on efficacy against cabbage aphids and rice plant hoppers were conducted by the respective crop protection station of Guangxi Academy of Agricultural Sciences and Anhui Academy of Agricultural Sciences (by commission)
2011: guadipyr was officially named “”戊吡虫胍”” by the Pesticide Standardisation Administration of the People’s Republic of China, enabling registrations and related field tests for guadipyr TC and formulations to take place

According to Xingyu Chemical, guadipyr is harmless to a number of organisms, such as aquatic life (like scenedesmus obliquus, daphnia magna and zebra fish), amphibians (like African clawed frogs), soil organisms (like earthworms), Japanese quail and Italian bees. In particular, this product is much less toxic to bees than many other neonicotinoid insecticides. Tests on mice showed that guadipyr is of micro toxicity – LD50>5,000 mg/kg (b.w.) in acute oral toxicity tests, LD50>5,000 mg/kg (b.w.) in acute percutaneous toxicity tests and LC50>3,458 mg/m3 in acute inhalation toxicity tests.

Notably, “”Guadipyr is an excellent substitute for imidacloprid. It shows lower toxicity and greater efficacy,”” disclosed Xingyu Chemical, “”We conducted field tests in Shandong, Anhui, Fujian and Jiangxi provinces and Guangxi Zhuang Autonomous Region and found this product to be especially effective against pests from the families of aphididae (such as aphids on cowpea, green peach, mealy plum, cotton, turnip, cabbage and rape), delphacidae (such as rice plant hopper), aleyrodidae (such as silverleaf whitefly) and lepidoptera (such as cotton bollworm and beet armyworm).””

Guadipyr has great market potential – it has an innovative chemical structure, high insecticidal activity, low toxicity, is environmentally friendly, and has no effect on non-targeted organisms while also targeting multiple pests (which can significantly reduce risk of resistance to it). The insecticide also has a simple production process and low production costs. For these reasons, guadipyr is expected to be competitive in the insecticide market.

Despite the fact that neonicotinoids have been the most widely used insecticides worldwide for many years, usage has been hindered by their high toxicity towards bees. In light of this, many pesticide manufacturers have increased efforts to overcome this obstacle.

Bayer CropScience’s flupyradifurone is a good example of a low toxicity neonicotinoid. Acute and chronic toxicity tests have shown that the product has a low toxicity towards bees (including adults and larvae). No serious impact will be posed to worker bees, the larvae, bee colonies, beehives or winter bee clusters if it is applied within the recommended usage amount, even if used during the flowering period.

On 14 Nov., 2016, flupyradifurone was registered by Bayer CropScience for the first time in China, suggesting a launch on the Chinese market in the near future. China aside, this insecticide has already been registered and launched in many other counties, and has been developing rapidly so far. Given its outstanding efficacy, innovative mechanism of action and harmlessness towards bees in particular, flupyradifurone is also expected to enjoy promising market prospects in China.”



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