Asia-Pacific region accounted for the largest market share of N-bromosuccinimide in 2015 and will continue to maintain

Date: 2016-09-12

N-Bromosuccinimide (NBS) is a brominating and oxidizing agent that is used as source for bromine in radical reactions (for example: allylic brominations) and various electrophilic additions. The NBS bromination of substrates such as alcohols and amines, followed by elimination of HBr in the presence of a base, leads to the products of net oxidation in which no bromine has been incorporated.

NBS is commercially available. It can also be synthesized in the laboratory. To do so, sodium hydroxide and bromine are added to an ice-water solution of succinimide. The NBS product precipitates out and can be collected by filtration.
Crude NBS gives better yield in the Wohl-Ziegler reaction. In other cases, impure NBS (slightly yellow in color) may give unreliable results. It can be purified by recrystallization from 90–95 °C water (10 g of NBS for 100 mL of water).

Although NBS is easier and safer to handle than bromine, precautions should be taken to avoid inhalation. NBS should be stored in a refrigerator. NBS will decompose over time giving off bromine. Pure NBS is white, but it is often found to be off-white or brown colored by bromine.

In general, reactions involving NBS are exothermic. Therefore, extra precautions should be taken when used on a large scale.

The global N-bromosuccinimide market is projected to grow at a CAGR of 4.0% within expectations. By the regions, Asia-Pacific is the largest market of N-bromosuccinimide, Europe and North America are relatively mature market for N-bromosuccinimide. Baed on the applications, pharmaceutical industry occupies the largest market share of N-bromosuccinimide, as more and more demand for drugs.

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Joanna | Executive – International Business and partner Relations
E-mail: | Tel: 1-510-400-8520

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